H2N2V1, Main, Exploration, bibRecord, 000898

Determinants of virulence of influenza A virus

Identifieur interne : 000898 ( Main/Exploration ); précédent : 000897; suivant : 000899

Determinants of virulence of influenza A virus

Auteurs : Eefje J. A. Schrauwen ; Miranda De Graaf ; Sander Herfst ; Guus F. Rimmelzwaan ; Albert D. M. E. Osterhaus ; Ron A. M. Fouchier

Source :

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [ 0934-9723 ] ; 2013.

RBID : PMC:3969785

Abstract

Influenza A viruses cause yearly seasonal epidemics and occasional global pandemics in humans. In the last century, four human influenza A virus pandemics have occured. Ocasionally, influenza A viruses that circulate in other species, cross the species barrier and infect humans. Virus re-assortment (i.e. mixing of gene segments of multiple viruses) and the accumulation of mutations contribute to the emergence of new influenza A virus variants. Fortunately, most of these variants do not have the ability to spread among humans and subsequently cause a pandemic. In this review we focus on the threat of animal influenza A viruses which have shown the ability to infect humans. In addition, genetic factors which could alter the virulence of influenza A viruses are discussed. Identification and characterization of these factors may provide insights into genetic traits which change virulence and help us to understand which genetic determinants are of importance for the pandemic potential of animal influenza A viruses.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969785

DOI: 10.1007/s10096-013-1984-8
PubMed: 24078062
PubMed Central: 3969785

Affiliations:

Le document en format XML

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<front><div type="abstract" xml:lang="en"><p id="P1">Influenza A viruses cause yearly seasonal epidemics and occasional global pandemics in humans. In the last century, four human influenza A virus pandemics have occured. Ocasionally, influenza A viruses that circulate in other species, cross the species barrier and infect humans. Virus re-assortment (i.e. mixing of gene segments of multiple viruses) and the accumulation of mutations contribute to the emergence of new influenza A virus variants. Fortunately, most of these variants do not have the ability to spread among humans and subsequently cause a pandemic. In this review we focus on the threat of animal influenza A viruses which have shown the ability to infect humans. In addition, genetic factors which could alter the virulence of influenza A viruses are discussed. Identification and characterization of these factors may provide insights into genetic traits which change virulence and help us to understand which genetic determinants are of importance for the pandemic potential of animal influenza A viruses.</p>
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Determinants of virulence of influenza A virus

Determinants of virulence of influenza A virus

Source :

Abstract

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Le document en format XML

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